Endocrine Abstracts

Introduction: The frequency of toxic multinoduler goiter (TMNG) is different among the countries depending on an intake of iodine, but it is said to be ~1% of adenomatous goiter in Japan. In addition, the frequency of TSH-secreting pituitary adenoma (TSHoma) is rare with 0.5–1.0% of pituitary gland tumor. There is no report that TMNG coexists in TSHoma so far.Case: A 58 years old female was complained swelling of thyroid and palpitation. We found se...

Here, we investigated roles of p38 MAPK pathway in the regulation of FSH-induced steroidogenesis using co-culture of rat primary granulosa cells with oocytes. The p38 protein was readily phosphorylated in granulosa cells by treatment with activin and FSH. The activin effect on p38 phosphorylation was abolished by a selective ALK-4, -5, -7 inhibitor SB431542. SB431542 suppressed FSH-induced estradiol production, but had no effect on progesterone production with a marginal reduc...

Objective: This study was designed to determine whether TRAb levels are correlated with the activity and severity of Graves’ ophthalmopathy (GO).Subjects and Methods: The subjects were 179 untreated Graves’ disease patients. TRAb was assayed with Elecsys TRAb at the initial visit, and an ophthalmic assessment was performed within 3 months. The activity of the ophthalmopathy was assessed by clinical activity scores (CASs) and MRI T2 relaxation t...

Context: Postpartum hyperthyroidism (PH) is one of the postpartum thyroid disorders that occurs during the first year postpartum and PH is caused by destructive thyroiditis and recurrent Graves’ disease. PH is an exacerbation of an underlying autoimmune thyroiditis that is aggravated by the immunological rebound that follows the partial immunosuppression that occurs during pregnancy. The prevalence of PH among women with Graves’ disease (GD) who had been treated with...

Primary aldosteronism (PA) is the most major cause of secondary hypertension, with its prevalence ranging from 3 to 20% of the hypertensive patients. Although guideline for diagnosis of PA has been established by the Endocrine Society, details of its applicability remain to be elucidated. In this study, we investigated the applicability of each step of the guideline in hypertensive patients by the multi-center collaborative study of National Hospital Organization (NHO) in Japa...